Effect of catalyst loading on synthesis of 2,4,6-triphenylpyridinea.
Entry | Catalyst loading (mol%) | Yieldb (%) |
---|---|---|
1 | None | 21 |
2 | 0.1 | 43 |
3 | 0.5 | 79 |
4 | 1 | 93 |
5 | 1.5 | 93 |
Reaction condition: benzaldehyde (1 mmol), acetophenone (2 mmol), ammonium acetate (1.5 mmol), HNTf2 catalyst at 80 °C for 50 min under solvent-free conditions.
Isolated yield.