Effect of temperature on the synthesis of 2,4,6-triphenylpyridinea.
Entry | Temp. (°C) | Yieldb (%) |
---|---|---|
1 | Room temp. | — |
2 | 45 | 36 |
3 | 60 | 67 |
4 | 80 | 93 |
5 | 85 | 93 |
Reaction condition: benzaldehyde (1 mmol), acetophenone (2 mmol), ammonium acetate (1.5 mmol), HNTf2 (1 mol%) at different temperature for 50 min under solvent-free conditions.
Isolated yield.