Fig. 6. miR-124 and miR-142 enhanced chemosensitivity in vivo. BABL/c nude mice were injected subcutaneously with miR-NC, miR-124, miR-nc, or miR-142-transfected H1299/CDDP cells, and then treated with 10 mg kg−1 CDDP when tumor volume was about 60 mm3. (A) Tumor volume was measured at different periods after treatment. (B) Tumor weight was detected at end point. (C) miR-124 and miR-142 expressions in tumor tissues were detected by qRT-PCR. (D) The protein expression of SIRT1 in tumor was determined by western blot assay. *P < 0.05.
