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. 2022 May 3;14:46. doi: 10.1186/s13073-022-01049-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Pseudotime analysis reveals the distinct trajectories of memory-like NK cell differentiation during ageing. A–C Trajectories predicted using the PAGA algorithm for NK1.1, NK2.1, NK2.2, and NK2.3 cells from young and elderly individuals. Cells are coloured by NK cell subsets (A), by the pseudotime trajectory (B), and by age group (C). D Pie charts showing the composition of NK cell subsets in five bins; each bin was divided equally according to the pseudotime of the cells. E Violin plots of the cell pseudotime distribution for each NK cell subset from young and elderly individuals. P-values were estimated by Wilcoxon rank-sum test. F The box plot shows the expression of the top 50 age-associated genes (obtained from Peters et al. [31]) of NK2.1, NK2.2, and NK2.3 cells from young people and elderly people. P-values were obtained using the Wilcoxon rank-sum tests. G Dot plot representing the expression of age-related genes of NK2.1, NK2.2, and NK2.3 cells in the young and elderly groups. The plot shows genes expressed by at least 20% of the cells in the subset. The size of the dot represents the fraction of cells expressing the gene, and the colour of the dot represents the gene level as a z-score