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. 2022 May 3;14:46. doi: 10.1186/s13073-022-01049-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Age-associated memory-like CD52⁺ NK2 cells (NK2.1) exhibit proinflammatory characteristics and display a type I IFN response state. A Representative flow cytometry analysis of the percentage of NK2.1 cells within NK2 cells (Lin⁻CD7⁺NKG2C⁺CD122^low) from young (left) and elderly (right) individuals. B Bar graphs showing the proportion of NK2.1 cells among NK cells (left) and among lymphocytes (right) from young (n = 35) and elderly (n = 27) individuals. C Representative density plots showing the expression of IFN-γ in NK2.1 cells from young and elderly individuals with or without IFN-α stimulation in vitro. D Bar graphs displaying the frequencies of IFN-γ⁺ cells in NK2.1 cells from young (n = 13) and elderly (n = 12) individuals with or without IFN-α stimulation in vitro. E Representative density plots showing the expression of CD107a in NK2.1 cells from young and elderly individuals with or without IFN-α stimulation in vitro. F Bar graphs displaying the frequencies of CD107a⁺ cells in NK2.1 cells from young (n = 7) and elderly (n = 7) individuals with or without IFN-α stimulation in vitro