Figure 2.

Representative scheme with regarding pharmacological activities and molecular mechanisms of bergapten. ↑: increased; ↓: decreased; mRNA: messenger ribonucleic acid; LDL: low-density lipoprotein; ROS: reactive oxygen species; NO: nitric oxide; iNO: inducible nitric oxide; RANK: receptor activator of nuclear factor-κB; P13k/Akt: phosphoinositide-3-kinase–protein kinase B/Akt; NF-κB: nuclear factor kappa light chain enhancer of activated B cells; NFATc1: nuclear factor-activated T cells c1; TNF-α: tumor necrosis alpha; COX: cyclooxygenase; IL-6: interleukin-6; HIV: human immunodeficiency virus.