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. 2022 Apr 25;2022:8615242. doi: 10.1155/2022/8615242

Table 1.

Selected studies reporting the pharmacokinetics of oral bergapten (1.2 mg/kg).

Reference Formulation Pharmacokinetic parameter
C max(ng/L) t max (h) AUC (ng/L·h) t 1/2 (h)
Nonfasted conditions
Aubin et al. [16] M 320 0.9 ND ND
UM 86 3.8 ND ND
Stolk et al. [17] M 322 2.7 942 ND
UM 108 3.3 276 ND
Treffel et al. [18] M 249 1.5 890 3.2
UM 68 3.0 272 2.2

Fasted conditions
Brodie et al. [19] M 177 1.6 433 1.4
UM 19 3.4 64 2.0
[20] M 32 2.0 140 1.7
LS 71 2.0 262 2.3

AUC: area under the plasma concentration curve; Cmax: maximum plasma concentration; LS: gelatin encapsulated liquid suspension; M: micronized; ND: not described; tmax: time to Cmax; UM: unmicronized.