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. 2022 Apr 25;2022:5497991. doi: 10.1155/2022/5497991

Figure 6.

Figure 6

LA suppressed GC growth and metastasis in VEGF-stimulated MKN-45 cells through PI3K/AKT and MEK/ERK signaling pathway activation. (a) Western blot analysis of PI3K, p-PI3K, AKT, p-AKT, MEK, p-MEK, ERK, and p-ERK in LA-treated VEGF-stimulated MKN-45 cells. (b and c) RT-PCR analysis of PI3K, AKT, MEK, and ERK mRNA relative expression in LA-treated VEGF-stimulated MKN-45 cells. The data are presented as mean ± SD (n = 3). ∗p < 0.05 vs. VEGF 0 ng/mL + LA 0 μM and ∗∗p < 0.01 vs. VEGF 0 ng/mL + LA 0 μM. #p < 0.05 vs. VEGF 20 ng/mL + LA 0 μM, ##p < 0.01 vs. VEGF 20 ng/mL + LA 0 μM.