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. 2022 Apr 25;2022:5013622. doi: 10.1155/2022/5013622

Figure 1.

Figure 1

LIRA inhibits the osteogenic transformation of VSMC in the thoracic aorta of DM rats. (a) IHC showed the expression of SMα-actin in the rat thoracic aorta (400x). In group DM + AS, 0 months vs. 2 months (P < 0.01) and 2 months vs. 4 months (P < 0.01). In months 2 and months 4, DM + AS vs. control (P < 0.01) and DM + AS + LIRA vs. DM + AS (P < 0.01); in group DM + AS, 0 months vs. 2 months (P < 0.01) and 2 months vs. 4 months (P < 0.01). Protein expression of (b) SMα-actin, (c) OPN, and (d) Cbfα-1. Data were from three independent experiments expressed as mean ± standard deviation. In month 2 and month 4, DM + AS vs. control (P < 0.01) and DM + AS + LIRA vs. DM + AS (P < 0.01). In group DM + AS, 0 months vs. 2 months (P < 0.01) and 2 months vs. 4 months (P < 0.01). ∗P < 0.01 vs. control; #P < 0.01 vs. DM + AS.