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. 2019 Mar 5;9(13):7239–7245. doi: 10.1039/c9ra00708c

Synergy test. Antibacterial activity of peptides combined with antibiotics. C (ciprofloxacin), V (vancomycin)a.

Bacterial strain Antibiotic Peptide MICA MICP A P FIC, index MICA/A Activity
Gram negative E. coli 25 922 C LfcinB (20–25)2 0.09 25 0.006 0.75 0.09 15 S
E. coli 11 775 C LfcinB (21–25)Pal 0.04 50 0.020 50 1.50 2 I
P. aeruginosa 27 853 C LfcinB (20–25)4 0.40 100 0.020 3.1 0.09 20 S
Gram positive E. faecalis 29 212 V LfcinB (20–30)4 6.4 400 0.200 12.5 0.06 32 S
LfcinB (21–25)Pal 6.4 200 0.100 25 0.14 64 S
S. aureus 25 923 V LfcinB (21–25)Pal 6.4 400 0.060 0.06 0.01 107 S
LfcinB (20–25)4 6.4 100 0.100 3.1 0.04 64 S
a

MICA, MICP,A and P in μg mL−1. S: synergy; I: indifference.