TABLE 2.
Candida susceptibility profile for commonly prescribed antifungal agents
| Species (no. [%]) and antifungal | MIC (μg/ml)
|
||
|---|---|---|---|
| Range | MIC50 | MIC90 | |
| C. albicans (235 [67.3]) | |||
| Fluconazole | 0.06–>64 | 0.25 | 1 |
| Itraconazole | 0.03–16 | 0.03 | 0.03 |
| Ketoconazole | 0.03–16 | 0.03 | 0.06 |
| Flucytosine | 0.03–64 | 0.25 | 2 |
| Amphotericin B | 0.03–0.5 | 0.25 | 0.5 |
| C. glabrata (52 [14.8]) | |||
| Fluconazole | 0.5–>64 | 16 | >64 |
| Itraconazole | 0.03–>16 | 0.5 | 4 |
| Ketoconazole | 0.03–16 | 0.5 | 2 |
| Flucytosine | 0.03–1 | 0.12 | 0.25 |
| Amphotericin B | 0.03–2 | 0.25 | 0.5 |
| C. tropicalis (21 [6.0]) | |||
| Fluconazole | 0.12–64 | 1 | 64 |
| Itraconazole | 0.03–16 | 0.06 | 16 |
| Ketoconazole | 0.03–16 | 0.03 | 2 |
| Flucytosine | 0.06–64 | 0.25 | 0.5 |
| Amphotericin B | 0.03–1 | 0.25 | 0.5 |
| C. krusei (11 [3.1]) | |||
| Fluconazole | 8–>64 | 32 | >64 |
| Itraconazole | 0.12–2 | 0.25 | 0.5 |
| Ketoconazole | 0.25–1 | 0.25 | 0.5 |
| Flucytosine | 0.06–1 | 8 | 16 |
| Amphotericin B | 0.12–2 | 0.5 | 1 |
| Othersa (30 [8.5]) | |||
| Fluconazole | 0.03–32 | 1 | 16 |
| Itraconazole | 0.03–0.25 | 0.03 | 0.25 |
| Ketoconazole | 0.03–0.5 | 0.03 | 0.12 |
| Flucytosine | 0.03–32 | 0.06 | 16 |
| Amphotericin B | 0.03–0.5 | 0.12 | 0.25 |
a
Others include 19 C. parapsilosis isolates, 5 C. lusitaniae isolates, 2 C. lambica isolates, 2 C. kefyr isolates, one C. lipolytica isolate, and one C. guilliermondii isolate.