Table 3.

Situations which may be contraindications for starting and/or continuation of OIT

-a patient and/or the family are not able to follow the OIT protocol for any reason (eg, scheduling conflicts, patient's athletic activities)

-a patient and/or their family have no access to epinephrine and/or are not able to properly use it when needed

-a patient has a confirmed history of previous frequent severe reactions

-a patient had multiple severe reactions to cow's milk OIT

-a patient has persistent gastrointestinal symptoms

-a patient has a concomitant asthma that is not well controlled

-a physician suggesting to use OIT is not able to devote sufficient time and resources to properly administering and monitoring OIT – this may require a 24 h per day, 7 days per week on-call service

-a preschool or school personnel does not accept providing and/or supervising milk OIT during school trips which might require the child to forgo school social activities or temporarily suspend the OIT