| Definite Familial Hypercholesterolemia: |
| • Adult with total cholesterol levels ≥ 290 mg/dL (> 7.5 mmol/L) or LDL-C ≥ 190 mg/dL (> 4.9 mmol/L) |
| • Child < 16 years of age with total cholesterol levels ≥ 260 mg/dL (> 6.7 mmol/L) or LDL-C ≥ 155 mg/dL (> 4.0 mmol/L) |
| PLUS EITHER |
| • Tendon xanthomas in the patient, or tendon xanthomas in a first degree relative (parent, sibling or child) or second degree relative (grandparent, aunt, or uncle) |
| OR |
| • Deoxynucleic acid based evidence of an LDL receptor mutation, familial defective apo B-100, or a PCSK9 mutation |
| Possible Familial Hypercholesterolemia: |
| • Adult with total cholesterol levels ≥ 290 mg/dL (>7.5 mmol/L) or LDL-C ≥ 190 mg/dL (>4.9 mmol/L) |
| • Child < 16 years of age with total cholesterol levels ≥ 260 mg/dL (>6.7 mmol/L) or LDL-C ≥ 155 mg/dL (>4.0 mmol/L) |
| PLUS AT LEAST ONE OF THE FOLLOWING: |
| • Family history of myocardial infarction in first degree relative < age 60 years |
| or second-degree relative < age 50 years |
| • Family history of an adult first- or second-degree relative with elevated total cholesterol ≥ 290 mg/dL (>7.5 mmol/L) or a child, brother or sister aged < 16 years with total cholesterol ≥ 260 mg/dL (> 6.7 mmol/L) |
