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. 2021 Dec 21;43(5):1156–1166. doi: 10.1038/s41401-021-00836-9

Fig. 1. Genome organization of the human GLP-1R gene and GLP-1R signaling.

Fig. 1

a The GLP-1R gene is located in chromosome 6 (6p21) and contains 13 exons interrupted by introns of varying lengths (0.4–8.1 kb). It encodes a protein of 463 amino acids consisting of signal peptide, ECD, and transmembrane domain (TMD). b Upon GLP-1 binding, the receptor recruits G protein trimers and converts guanosine triphosphate (GTP) to guanosine diphosphate (GDP) enabling Gα to dissociate and activate AC by converting ATP to cAMP. Release of stored calcium ions by the endoplasmic reticulum will follow to increase glucose-stimulated insulin secretion.