Fig. 1. LncRNA LINC00680 was induced by METTL3 in IL-1β-treated chondrocyte.

A m⁶A modification of RNAs was determined by m⁶A ELISA kit (Colorimetric assay). OA and normal groups respectively indicated the cartilage tissues collected from OA patients and no-OA patients. Control and IL-1β group indicated the chondrocytes treated with IL-1β (10 ng/mL) or blank. B METTL3 mRNA levels were detected using RT-PCR in cartilage tissues or IL-1β-treated chondrocyte. C Heat map showed the candidate lncRNAs’ levels detected using RT-PCR. D LINC00680 level was detected using RT-PCR in cartilage tissues or IL-1β-treated chondrocyte. Experiments’ data were repeated in triplicate. *Indicates the p < 0.05.