Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 18;32(5):451–460. doi: 10.1038/s41422-022-00633-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 7 — a An overall view of the IR scaffold. b An overall view on inter-subunit interface between subunit 1 (S1) and subunit 2 (S2). c A close-up view on the cytoplasmic side of the interface between S1 and S2. Given the spatial gap in between, Nup205 of S1 may not directly interact with Nup93-1 or Nup188 from S2. d The IR subunit is slightly tilted toward the cytoplasmic side. e The IR subunit is linked to the outer rings through the linker nucleoporins Nup93, NDC1, ALADIN, and Nup155-1. The IR subunit is connected in opposite directions to the outer rings. Such connection depends on the ALADIN–NDC1 hetero-dimer to fill up the vacancy between Nup155-1 and Nup93-2.