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. 2021 Aug 30;43(5):1311–1323. doi: 10.1038/s41401-021-00756-8

Fig. 7. FTO-mediated m6A modification decreased the PPARG mRNA level in a YTHDF2-dependent manner.

Fig. 7

a Metagene analysis of the m6A status of PPARG. b The m6A motif in PPARG. c Knockdown of FTO increased the mRNA expression level of PPARG. d Half-life of PPARG mRNA in BMSCs treated with an FTO inhibitor. e Knockdown of YTHDF1 diminished the induction of PPARG expression in BMSCs treated with an FTO inhibitor. f Knockdown of FTO induced m6A methylation of PPARG mRNA, as determined by YTHDF1-RIP. **P < 0.01; ***P < 0.001; n = 3.