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. 2022 Mar 18;32(5):437–450. doi: 10.1038/s41422-022-00632-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Overall view of subunits involved in the inter-layer interactions, with eye symbols and arrowheads indicating view directions shown in the following panels. b Interactions of Nup170-1 with Nup188-1 and Nup192-1. Two interfaces are boxed by blue and yellowgreen dashed lines and enlarged in d and e, respectively. c The concave surface at the junction of Nup188-1 and Nup192-1. The area contacting Nup170-1 is circled. d, e Details of the interaction of the C-terminal region of Nup170-1 with Nup188-1 (d) and Nup192-1 (e). f Details of the interaction between Nic96-B-1 and Nup188-1. g Overall view of subunits involved in the middle and inner layer interactions. Two interfaces are boxed by black dashed lines and enlarged in i and j, respectively. h Loops connecting CCD2 and CCD3 of CNT-A-1 protrude into the groove located in the “S” domain from Nup192-1. i Long stalked CCD1 and CCD2 of CNT-A-1 clamp the N-terminal corner of Nup192-1 by extensive contacts via α-helices and loops. j Details of the interaction between Nup188-1 and CNT-B-1. k CNT-A-1 blocks the hole located between NTD and CTD of Nup192-1.