Fig. 6.

Nsd2 promotes Treg migration into the decidua primarily by regulating CXCR4 expression. a Percentage of resorption observed in individual WT, CXCR4^{Treg KO}, and Nsd2/CXCR4^{Treg dKO} pregnancies resulting from mating with male BALB/c mice. b Percentage of resorbed embryos in all WT, CXCR4^{Treg KO}, and Nsd2/CXCR4^{Treg dKO} pregnancies resulting from mating with male BALB/c mice. Two-sided Fisher’s exact test was used to assess the significance. c Representative flow cytometric analysis of YFP⁺ Tregs in the decidua and analysis of the decidua of female WT, CXCR4^{Treg KO} and Nsd2/CXCR4^{Treg dKO} mice mated with male BALB/c mice and analyzed on Days E13.5–E14.5. n = 8. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001; ns not significant