Table 2.

Sequence comparison of human and bovine TG in the region encompassing hormonogenic site B.

Hormonogenic site-B is formed by the folding of four TG segments:
Segment 1: identity 88.2% and similarity 100% over 17 residues:
human 668 MQSLMGSQPAGSTLFVP 684
bovine 668 MQSLLGSQPAGSSLFVP 684
Segment 2: identity 100% and similarity 100% over 10 residues:
human 2467 TKLLAVSGPF 2476
bovine 2467 TKLLAVSGPF 2476
Segment 3: identity 96.9% and similarity 100% over 32 residues:
human 2515 GLINRAKAVKQFEESRGRTSSKTAFYQALQNS 2547
bovine 2515 GLINRAKAVKQFEESQGRTSSKTAFYQALQNS 2547
Segment 4: identity 86.4% similarity 90.9% over 22 residues:
human 2563 WYYSLEHSTDDYASFSRALENA 2584
bovine 2563 WYYSLEHDSDDYASFSRALEQA 2584
Overall site-B: identity 92.6% and similarity 97.5% over 81 residues
Overall TG conservation: identity 77.4% and similarity 85.9% over 2771 residues

The region is formed by four segments (Segments 1-4) comprising a total of 81 amino acid residues. Conservation was measured on the MBOSS-matcher using a BLOSUM62 evolution matrix.