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. 2022 Apr 30;8:39. doi: 10.1038/s41421-022-00399-x

Fig. 3. Genomic DNA 6mA content at global level significantly decreases in hypoxic human gliomas.

Fig. 3

a DNA 6mA content in glioma tissues. Normal brain tissues: n = 13; glioma tissues: n = 78. b DNA 6mA contents in glioma tissues and normal brain tissues. Normal brain tissues: n = 13; Astrocytoma (A) tissues: n = 20; Anaplastic Astrocytoma (AA) tissues: n = 18; Glioblastoma (GBM) tissues: n = 40. c DNA 6mA content in glioma tissues with IDH1mut being excluded. Normal brain tissues: n = 13; A tissues: n = 7; AA tissues, n = 8; GBM tissues: n = 39. d Hypoxia reduces misincorporated DNA in cultured human glioblastoma cells. Statistical significance was determined by Student’s unpaired t-test.