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. 2022 Apr 30;8:39. doi: 10.1038/s41421-022-00399-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Pearson correlations between 6mA level and overall survival time of GBM patients (n = 35). b Kaplan–Meier curve of GBM patients survival according to 6mA levels in GBM tissues. Patients were stratified into the “high level 6mA” group (n = 18) and the “low level 6mA” group (n = 17). c, d Kaplan–Meier curve of GBM patients survival according to 5mC (c) or 5hmC (d) levels in GBM tissues. Patients were stratified into the “high level 5mC/5hmC” group (n = 18) and the “low level 5mC/5hmC” group (n = 17). e Multivariate Cox proportional hazards ratios for survival based on 6mA level adjusted for 5mC and 5hmC of patients. f Multivariate Cox proportional hazards ratios for survival based on 6mA level adjusted for TERT promoter mutation and MGMT promoter methylation of patients. a Statistical significance was determined by Student’s unpaired t-test. b–d Significance was determined by log-rank analysis.