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. 2022 Apr 19;13:827470. doi: 10.3389/fphys.2022.827470

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Copyright © 2022 Chen, Zhang, Yang, Liu, Liu, Feng and Xuan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Odontogenic MSCs and their subpopulations. Various types of stem cells, such as dental pulp stem cells (DPSCs), periodontal ligament stem cells (PDLSCs) and stem cells from the root apical papilla (SCAPs), can be found in the dental pulp and periodontal ligament around the tooth root. Gli1⁺ MSCs surround the vasculature exclusively. Axin2⁺ MSCs were identified in the periodontal ligament (PDL). CD24a + MSCs were present in human dental papilla tissues.