TABLE 2.

Inducers and inhibitors of ferroptosis.

Classification	Reagents	Targets	Mechanisms	References
Ferroptosis inducers	Sulphasalazine	System Xc−	Cysteine deprivation	Gout et al. (2001)
	Sorafenib	System Xc−	Cysteine deprivation	Louandre et al. (2013); Louandre et al. (2015)
	Erastin	System Xc−, VDAC2/3	Cysteine deprivation	Dolma et al. (2003); Yagoda et al. (2007)
	RSL3	GPX4	GPX4 inactivation and GSH deletion	Yang et al. (2014)
	ML162	GPX4	GPX4 inactivation and GSH deletion	Moosmayer et al. (2021)
	FINO2	GPX4	GPX4 inactivation and lipid peroxides accumulation	Gaschler et al. (2018)
	FIN56	CoQ10 and GPX4	CoQ10 deletion and GPX4 inactivation	Shimada et al. (2016)
	BSO	GHS	GHS deletion	Yang et al. (2014)
	DPI2	GSH	GHS deletion	Yang et al. (2014)
	Cisplatin	GSH	Decreased GSH levels and GPX4 inactivation	Yamaguchi et al. (2013)
	Statins	HMG	CoQ10 deletion	Chen et al. (2021b)
	Siramesine	Ferroportin	Increased cellular iron	Ma et al. (2016)
	lapatinib	Transferrin	Increased cellular iron	Ma et al. (2016)
Ferroptosis inhibitors	Ferrostatin-1	ROS from lipid peroxidation	Inhibition of lipid peroxidation	Skouta et al. (2014)
	Liproxstatin-1	ROS from lipid peroxidation	Inhibition of lipid peroxidation	Friedmann Angeli et al. (2014)
	Vitamin E	ROS from lipid peroxidation	Inhibition of lipid peroxidation	Hinman et al. (2018)
	SRS 16–86	ROS from lipid peroxidation	Inhibition of lipid peroxidation	Linkermann et al. (2014a)
	SRS 11–92	ROS from lipid peroxidation	Inhibition of lipid peroxidation	Skouta et al. (2014)
	TEMPO	Radical-trapping antioxidant	Elimination of oxygen free radicals	Griesser et al. (2018)
	PMC	Radical-trapping antioxidant	Elimination of oxygen free radicals	Shah et al. (2017)
	Tetrahydronapthy-ridinols	Radical-trapping antioxidant	Elimination of oxygen free radicals	Angeli et al. (2017)
	Phenothiazine	Radical-trapping antioxidant	Elimination of oxygen free radicals	Shah et al. (2017)
	Phenoxazine	Radical-trapping antioxidant	Elimination of oxygen free radicals	Shah et al. (2017)
	Diarylamine	Radical-trapping antioxidant	Elimination of oxygen free radicals	Shah et al. (2017)
	XJB-5-131	Nitroxide antioxidant	Elimination of nitrogen oxides	Krainz et al. (2016)
	Baicalein	Lipoxygenases	Inactivation of lipoxygenase	Yang and Stockwell, (2016)
	BW A4C	Lipoxygenases	Inactivation of lipoxygenase	Angeli et al. (2017)
	AA-861	Lipoxygenases	Inactivation of lipoxygenase	Yang and Stockwell, (2016)
	CDC	Lipoxygenases	Inactivation of lipoxygenase	Yang and Stockwell, (2016)
	PD146176	Lipoxygenases	Inactivation of lipoxygenase	Yang and Stockwell, (2016)
	NDGA	Lipoxygenases	Inactivation of lipoxygenase	Probst et al. (2017)
	Zileuton	Lipoxygenases	Inactivation of lipoxygenase	Yang and Stockwell, (2016)
	Ciclopirox olamine	Intracellular iron	Decreased cellular iron	Dixon et al. (2012)
	2,2′-bipyridyl	Intracellular iron	Decreased cellular iron	Dixon et al. (2012)
	Deferoxamine mesylate	Intracellular iron	Decreased cellular iron	Yang and Stockwell, (2008)
	Deferoxamine	Intracellular iron	Decreased cellular iron	Dixon et al. (2012)