Table 3.
Risk of preterm birth of women living with HIV receiving different PI-ART regimens.
| ATV/r-ART | NFV-ART | DRV/r-ART | FPV/r-ART | IDV/r-ART | IDV-ART | SQV/r-ART | SQV-ART | TPV/r-ART | |
|---|---|---|---|---|---|---|---|---|---|
| RR (95%CI) | RR (95%CI) | RR (95%CI) | RR (95%CI) | RR (95%CI) | RR (95%CI) | RR (95%CI) | RR (95%CI) | RR (95%CI) | |
| LPV/r-ART | 0.98 (0.75, 1.27) |
1.33 (1.03, 1.72) |
0.83 (0.36, 1.95) |
1.09 (0.54, 2.22) |
1.68 (0.43, 6.65) |
1.08 (0.65, 1.81) |
2.99 (0.43, 20.92) |
1.90 (0.13, 27.28) |
|
| ATV/r-ART | 1.63 (0.91, 2.92) |
0.92 (0.55, 1.55) |
0.90 (0.12, 6.98) |
0.54 (0.07, 4.04) |
2.70 (0.62, 11.72) |
0.54 (0.08, 3.77) |
4.80 (0.64, 35.91) |
3.10 (0.21, 46.34) |
|
| NFV-ART | 0.52 (0.20, 1.32) |
0.66 (0.28, 1.53) |
1.06 (0.27, 4.19) |
0.65 (0.33, 1.30) |
1.89 (0.27, 13.19) |
1.20 (0.08, 17.25) |
|||
| DRV/r-ART | |||||||||
| FPV/r-ART | 1.44 (0.47, 4.42)) |
0.76 (0.04, 13.43) |
1.43 (0.52, 3.91) |
1.13 (0.05, 23.72) |
|||||
| IDV/r-ART | 0.99 (0.43, 2.31) |
||||||||
| IDV-ART | 1.78 (0.18, 17.80) |
1.32 (0.07, 23.26) |
|||||||
| SQV/r-ART | |||||||||
| SQV-ART | 0.88 (0.04, 18.47) |
||||||||
Random-effects meta-analysis results for risk of preterm birth associated with women living with HIV receiving ART regimens containing different protease inhibitors (PIs). Relative risk (RR) and 95% confidence interval (95% CI) are displayed. A RR > 1 indicates increased risk of a preterm birth associated with the ART regimen in the row compared to the regimen in the column. For example, LPV/r-ART is associated with an increased risk of preterm birth compared to NFV-ART (RR 1.33, 95% CI 1.03–1.72). Forest plots of pairwise meta-analyses of ART regimens containing different protease inhibitors can be found in Appendix pp 36–74.
Abbreviations: ART = antiretroviral therapy, ATV/r = atazanavir/ritonavir, DRV/r = darunavir/ritonavir, FPV/r = fosamprenavir/ritonavir, HIV = human immunodeficiency virus, IDV = indinavir, IDV/r = indinavir/ritonavir, LPV/r = lopinavir/ritonavir, NFV = nelfinavir, PI = protease inhibitor, SQV/r = saquinavir/ritonavir, SQV = saquinavir, TPV/r = tipranavir/ritonavir.