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. 2022 Apr 19;13:853648. doi: 10.3389/fgene.2022.853648

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Copyright © 2022 Zhen, Shen and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Landscape of genetic and expression variation of ICGs in GC. (A) Interaction of several specific immune checkpoint molecules. (B) Potential biological function enrichment of 31 ICGs. (C) The CNV variation frequency of ICGs in TCGA-STAD cohort. (D) The location of CNV alteration of ICGs on 23 chromosomes in TCGA-STAD cohort. (E) The mutation frequency of 31 ICGs in GC patients from TCGA-STAD cohort. (F) The expression of 31 ICGs between normal tissues and GC tissues. *p < 0.05, **p < 0.01, ***p < 0.001.