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. 2022 Apr 19;13:853648. doi: 10.3389/fgene.2022.853648

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Copyright © 2022 Zhen, Shen and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional enrichment analysis of three immune checkpoint regulation patterns. (A–C) GSVA enrichment analysis showing the activation states of biological pathways in distinct immune checkpoint regulation patterns. (D) The abundance of each TME infiltrating cell in three immune checkpoint regulation patterns using ssGSEA. (E) The abundance of immune cell infiltration of GSE62254 cohort using CIBERSORT. (F–H) The contents of immune cells and stromal cells in GC samples of GSE62254 cohort using ESTIMATE. (I,J) Functional annotation for immune checkpoint-related genes using GO and KEGG enrichment analysis.