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. 2022 Apr 19;13:853648. doi: 10.3389/fgene.2022.853648

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Copyright © 2022 Zhen, Shen and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Establishment of ICscore signatures. (A) Consistent clustering matrices based on 1,248 immune checkpoint-related genes for k = 2. (B) Survival analyses for immune checkpoint gene signatures based on 1174 GC patients. (C) Unsupervised clustering of overlapping immune checkpoint-related genes to classify patients into two genomic subtypes. (D) The expression of 31 ICGs in two clusters. (E) Alluvial diagram showing the changes of ICGcluster, geneCluster, ICscore and survival status. (F) Correlations between ICscore and the TME infiltrating cell. (G–H) Differences in ICscore among three ICGclusters and geneClusters. (I) GC patients were divided into two subgroups according to the optimal cutoff value of ICscore. (J) Survival analyses for low and high ICscore patient groups. (K) Survival distribution of low and high ICscore patient groups.