Fig. 3. DSF and DSC were used to test the stabilization of TyrRS by RSV and compound 11. (A) The Tm value of compound 11. (B) The Tm value of RSV. Also shown are graphs of the unfolding transition of 2 μM TyrRS in the presence of 50 μM RSV or compound 11, respectively. (C and D) Representative DSC melting profiles for TyrRS with RSV or compound 11; ΔTm of RSV and compound 11 obtained from DSC.
