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. 2022 Apr 19;10:875155. doi: 10.3389/fcell.2022.875155

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Copyright © 2022 Tangeman, Pérez-Estrada, Van Zeeland, Liu, Danciutiu, Grajales-Esquivel, Smucker, Liang and Del Rio-Tsonis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clustering of differentially expressed genes reveals expression programs associated with RPE commitment and reprogramming. (A) Affinity propagation clustering was performed on all genes that are differentially expressed across the E4 to E5 window by the criteria |LFC| ≥ 1 and adj. p-value ≤ 0.05 (n = 2551), resulting in six clusters. Key genes are summarized on the right of heatmap. The heatmap intensity displays row-normalized gene counts. (B) Bubble charts display select gene ontology terms associated with each cluster. Adj. p-value is plotted on y-axis and the bubble size is proportional to number of terms identified in the analysis.