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. 2022 Apr 19;10:875155. doi: 10.3389/fcell.2022.875155

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Copyright © 2022 Tangeman, Pérez-Estrada, Van Zeeland, Liu, Danciutiu, Grajales-Esquivel, Smucker, Liang and Del Rio-Tsonis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overrepresented motifs in open regions of the E4/E5 RPE. The monaLisa motif analysis software was used to bin differentially accessible summits by accessibility across the E4 and E5 conditions. Each bin was analyzed for the overrepresentation of transcription factor motifs found in the JASPAR 2022 database. Enriched motifs identified at −log(p-Adj.) >3 in any bin were recorded and select factors associated with the developing RPE (A) or 6hPR + FGF2 (B) samples were plotted. (C) Genome browser displays ATAC-signal proximal to DARs containing the OTX2 binding motif. The region of interest is highlighted in pink and associated motifs are summarized below the track.