Table 3.

Abnormal resting state neural activity in subjects with Pathological Internet Use (PIU) compared with healthy controls (HC) (voxels ≥ 20).

Cluster No.	Voxels (voxels)	SDM-Z	P-value	Brain region	Brodmann area	MNI coordinate			I 2	Meta bias test (p-value)
						x	y	z
PIU > HCs
1	408	3.820	0.00007	(Undefined)	BA 28	−26	4	−26	7.20%	0.922
		3.705	0.00011	LSTGtp	BA 38	−26	12	−30
		3.531	0.00021	L AMY	BA 28	−22	−4	−24
		2.953	0.00158	L AMY	BA 34	−30	−4	−14
		2.823	0.00238	L AMY	BA 34	−26	−2	−14
2	364	3.609	0.00015	L MCC	BA 23	0	−12	38	8.04%	0.683
		3.420	0.00031	L MCC	BA 23	−4	−22	44
		3.388	0.00035	R MCC	BA 23	2	−10	34
		3.371	0.00037	R MCC	BA 23	8	−20	42
3	21	2.953	0.00157	R IN	BA 48	34	−6	10	2.15%	0.999
PIU < HCs
4	30	−3.110	0.00093	L SFGdl	BA 11	−28	60	0	23.33%	0.489
5	20	−3.199	0.00068	R MFG	BA 11	32	58	0	17.21%	0.5

L, left; R, right; HCs, healthy controls; PIU, pathological Internet use; AMY, Amygdala; BA, Brodmann area; IN, insula; MCC, median cingulate cortex; MFG, middle frontal gyrus; MNI, Montreal neurological institute; SFGdl, dorsolateral superior frontal gyrus; STGtp, temporal pole of the superior temporal gyrus; 1 voxel was 2mm × 2mm × 2mm.