. 2022 Apr 18;16:835717. doi: 10.3389/fnbeh.2022.835717

TABLE 2.

Student’s t-test for anxiety-like behavior evaluated in the elevated plus maze.

	Protocol period
	14:7-7			21:7-14			21:14-7			28:14-14
Behavior	Control	Cagemate		Control	Cagemate		Control	Cagemate		Control	Cagemate
Open arm entries (%)	29.7 ± 3.0	30.4 ± 5.1	t₍₂₇₎ = −0.14; p = 0.89	40.0 ± 6.6	39.3 ± 9.2	t₍₂₄₎ = 0.07; p = 0.95	28.9 ± 6.4	23.2 ± 8.0	t₍₂₅₎ = 0.54; p = 0.60	39.7 ± 4.0	18.6 ± 4.4#	t₍₁₇₎ = 3.51; p < 0.05
Open arm time (%)	18.7 ± 2.3	23.6 ± 4.7	t₍₂₇₎ = −1.01; p = 0.32	28.5 ± 6.2	28.5 ± 8.3	t₍₂₄₎ = −0.01; p = 0.99	15.8 ± 5.3	13.8 ± 5.3	t₍₂₅₎ = 0.24; p = 0.82	22.1 ± 4.9	10.2 ± 3.1§	t₍₁₇₎ = 2.09; p = 0.052
Closed arm entries (frequency)	9.1 ± 0.7	10.9 ± 0.8	t₍₂₇₎ = −1.82; p = 0.08	7.0 ± 0.9	7.7 ± 1.4	t₍₂₄₎ = −0.42; p = 0.68	6.0 ± 0.6	8.6 ± 1.6	t₍₂₅₎ = −1.83; p = 0.08	9.4 ± 0.9	10.3 ± 0.8	t₍₁₇₎ = −0.68; p = 0.51
Center time (%)	37.3 ± 2.2	31.9 ± 2.2	t₍₂₇₎ = 1.56; p = 0.13	42.6 ± 4.8	44.7 ± 4.7	t₍₂₄₎ = −0.28; p = 0.78	38.7 ± 4.8	33.3 ± 4.3	t₍₂₅₎ = 0.71; p = 0.49	23.9 ± 2.8	34.9 ± 3.3#	t₍₁₇₎ = −2.45; p < 0.05
SAP (frequency)	50.2 ± 2.6	17.2 ± 2.0#	t₍₂₇₎ = 9.19; p < 0.05	45.4 ± 3.1	46.3 ± 2.8	t₍₂₄₎ = −0.17; p = 0.87	45.0 ± 3.3	45.1 ± 2.5	t₍₂₅₎ = −0.01; p = 0.99	20.2 ± 3.7	19.2 ± 3.4	t₍₁₇₎ = 0.20; p = 0.84
Protected SAP (%)	78.3 ± 2.6	89.2 ± 2.8#	t₍₂₇₎ = −2.75; p < 0.05	70.9 ± 6.5	68.0 ± 7.0	t₍₂₄₎ = 0.26; p = 0.80	81.3 ± 5.3	84.8 ± 5.1	t₍₂₅₎ = −0.41; p = 0.68	78.8 ± 5.3	98.0 ± 1.0#	t₍₁₇₎ = −3.68; p < 0.05
Head-dipping (frequency)	24.7 ± 2.4	34.4 ± 1.9#	t₍₂₇₎ = −2.94; p < 0.05	28.7 ± 2.4	37.7 ± 3.9	t₍₂₄₎ = −1.77; p = 0.09	21.3 ± 1.2	20.5 ± 4.7	t₍₂₅₎ = 0.22; p = 0.83	27.4 ± 3.6	34.4 ± 3.4	t₍₁₇₎ = −1.38; p = 0.19
Protected head-dipping (%)	69.9 ± 4.6	63.1 ± 6.1	t₍₂₇₎ = 0.90; p = 0.38	29.3 ± 8.3	62.9 ± 8.3 #	t₍₂₄₎ = −2.39; p < 0.05	37.1 ± 10.1	74.8 ± 6.7#	t₍₂₅₎ = −2.45; p < 0.05	16.6 ± 2.1	29.6 ± 2.8 #	t₍₁₇₎ = −4.14; p < 0.05

#p < 0.05 vs. respective control group. §p = 0.052 vs. respective control group.