TABLE 1.
Comparative in vitro activity of ABT-773 by agar dilution methods
| Species (resistance) [n] and antibiotic | MIC (μg/ml)
|
||
|---|---|---|---|
| Range | 50% | 90% | |
| S. pyogenes (macrolide S) [17] | |||
| ABT-773 | ≤0.015–0.03 | 0.03 | 0.03 |
| Clarithromycin | 0.03 | 0.03 | 0.03 |
| Azithromycin | 0.12–0.25 | 0.12 | 0.25 |
| Erythromycin | 0.03–0.06 | 0.03 | 0.06 |
| Clindamycin | 0.03–0.06 | 0.03 | 0.06 |
| S. pyogenes (MefA) [13] | |||
| ABT-773 | ≤0.015–0.25 | 0.12 | 0.25 |
| Clarithromycin | 2–16 | 4 | 16 |
| Azithromycin | 2–8 | 8 | 8 |
| Erythromycin | 2–16 | 8 | 16 |
| Clindamycin | ≤0.015–0.06 | 0.06 | 0.06 |
| S. pyogenes (inducible ErmA) [11] | |||
| ABT-773 | ≤0.015–>1 | 0.03 | 0.12 |
| Clarithromycin | 2–>64 | 8 | 8 |
| Azithromycin | 8–>128 | 32 | 128 |
| Erythromycin | 2–128 | 16 | 16 |
| Clindamycin | 0.03–0.5 | 0.12 | 0.5 |
| S. pyogenes (constitutive ErmB) [6] | |||
| ABT-773 | 0.5–8 | ||
| Clarithromycin | >128 | ||
| Azithromycin | >128 | ||
| Erythromycin | >128 | ||
| Clindamycin | 128–>128 | ||
| S. aureus (macrolide S) [16] | |||
| ABT-773 | 0.03 | 0.03 | 0.03 |
| Clarithromycin | 0.12–0.25 | 0.12 | 0.25 |
| Azithromycin | 0.25–1 | 0.5 | 1 |
| Erythromycin | 0.25 | 0.25 | 0.25 |
| Clindamycin | 0.06–0.12 | 0.12 | 0.12 |
| S. aureus (inducible ErmA) [11] | |||
| ABT-773 | 0.03–0.25 | 0.03 | 0.25 |
| Clarithromycin | 2–>128 | >128 | >128 |
| Azithromycin | 8–>128 | >128 | >128 |
| Erythromycin | 4–>128 | >128 | >128 |
| Clindamycin | 0.06–0.12 | 0.06 | 0.06 |
| S. aureus (constitutive ErmA, ErmC) [18] | |||
| ABT-773 | >128 | >128 | >128 |
| Clarithromycin | >128 | >128 | >128 |
| Azithromycin | >128 | >128 | >128 |
| Erythromycin | >128 | >128 | >128 |
| Clindamycin | >128 | >128 | >128 |
| S. epidermidis (macrolide S) [13] | |||
| ABT-773 | ≤0.015–0.03 | 0.03 | 0.03 |
| Clarithromycin | ≤0.015–0.25 | 0.12 | 0.25 |
| Azithromycin | ≤0.12–1 | 0.5 | 1 |
| Erythromycin | ≤0.03–0.25 | 0.25 | 0.25 |
| Clindamycin | 0.06–0.12 | 0.06 | 0.12 |
| S. epidermidis (constitutive MLSB) [12] | |||
| ABT-773 | >128 | >128 | >128 |
| Clarithromycin | >128 | >128 | >128 |
| Azithromycin | >128 | >128 | >128 |
| Erythromycin | >128 | >128 | >128 |
| Clindamycin | >128 | >128 | >128 |
| Enterococcus spp. (macrolide S) [12] | |||
| ABT-773 | ≤0.015–0.03 | 0.03 | 0.03 |
| Clarithromycin | 0.12–0.5 | 0.25 | 0.5 |
| Azithromycin | 0.25–2 | 1 | 2 |
| Erythromycin | 0.06–0.5 | 0.25 | 0.5 |
| Clindamycin | 0.25–32 | 16 | 16 |
| Enterococcus spp. (macrolide R) [30] | |||
| ABT-773 | 1–>128 | 16 | 128 |
| Clarithromycin | >128 | >128 | >128 |
| Azithromycin | >128 | >128 | >128 |
| Erythromycin | >128 | >128 | >128 |
| Clindamycin | >128 | >128 | >128 |
| Corynebacterium spp. [18] | |||
| ABT-773 | 0.002–0.5 | 0.015 | 0.5 |
| Clarithromycin | 0.008–>64 | 4 | 64 |
| Azithromycin | 0.03–>128 | >128 | >128 |
| Erythromycin | 0.004–>128 | 8 | 128 |
| Clindamycin | 0.12–>128 | >128 | >128 |
| L. monocytogenes [24] | |||
| ABT-773 | 0.03 | 0.03 | 0.03 |
| Clarithromycin | 0.12 | 0.12 | 0.12 |
| Azithromycin | 1 | 1 | 1 |
| Erythromycin | 0.12 | 0.12 | 0.12 |
| E. coli [28] | |||
| ABT-773 | 2–64 | 16 | 64 |
| Clarithromycin | 32–>128 | 128 | >128 |
| Azithromycin | 2–16 | 4 | 16 |
| Erythromycin | 32–>128 | 128 | >128 |
| M. catarrhalis [17] | |||
| ABT-773 | 0.06–0.12 | 0.12 | 0.12 |
| Clarithromycin | 0.12–0.25 | 0.12 | 0.25 |
| Azithromycin | 0.015–0.06 | 0.03 | 0.06 |
| Erythromycin | 0.12–0.25 | 0.12 | 0.25 |
| Legionella spp. [11] | |||
| ABT-773 | 0.5–1 | 0.5 | 1 |
| Clarithromycin | 0.06–0.12 | 0.12 | 0.12 |
| Azithromycin | 0.12–2 | 0.5 | 2 |
| Erythromycin | 0.25–1 | 1 | 1 |
| N. gonorrhoeae [11] | |||
| ABT-773 | ≤0.008–0.5 | 0.015 | 0.25 |
| Clarithromycin | 0.015–2 | 0.06 | 1 |
| Azithromycin | 0.03–0.25 | 0.03 | 012 |
| Erythromycin | 0.015–4 | 0.12 | 1 |
| H. pylori (macrolide S) [15] | |||
| ABT-773 | 0.008–0.06 | 0.03 | 0.06 |
| Clarithromycin | 0.008–0.06 | 0.008 | 0.015 |
| Azithromycin | 0.06–0.5 | 0.25 | 0.5 |
| Erythromycin | 0.06–0.25 | 0.12 | 0.25 |
| H. pylori (macrolide R) [15] | |||
| ABT-773 | 4–64 | 32 | 64 |
| Clarithromycin | 4–128 | 32 | 128 |
| Azithromycin | 128–>128 | >128 | >128 |
| Erythromycin | 64–>128 | 128 | >128 |
| M. avium (macrolide S) [13] | |||
| ABT-773 | 0.5–128 | 32 | 64 |
| Clarithromycin | 0.25–32 | 4 | 16 |
| Azithromycin | 16–>256 | 64 | >256 |
| Erythromycin | 4–>256 | 64 | 256 |
| M. avium (macrolide R) [15] | |||
| ABT-773 | >256 | >256 | >256 |
| Clarithromycin | >256 | >256 | >256 |
| Azithromycin | >256 | >256 | >256 |
| Erythromycin | >256 | >256 | >256 |