TABLE 3.
Minimum bactericidal activities of ABT-773a
| Species | ABT-773
|
Erythromycin
|
Ciprofloxacin
|
|||
|---|---|---|---|---|---|---|
| MIC | MBC | MIC | MBC | MIC | MBC | |
| S. pneumoniae ATCC 6303 | ||||||
| No serum | 0.002 | 0.004 | 0.03 | 0.12 | 1 | 1 |
| Serum | 0.004 | 0.008 | 0.06 | 2 | 1 | 2 |
| H. influenzae 1882 | ||||||
| No serum | 0.5 | 1 | 4 | 8 | 0.004 | 0.008 |
| Serum | 0.5 | 1 | 1 | 2 | 0.004 | 0.004 |
| M. catarrhalis 2604 | ||||||
| No serum | 0.25 | 0.5 | 0.25 | 0.5 | 0.12 | 0.12 |
| Serum | 0.12 | 0.12 | 0.12 | 0.12 | 0.12 | 0.12 |
| S. aureus ATCC 6538P | ||||||
| No serum | 0.03 | >1 | 0.25 | >8 | 0.12 | 0.25 |
| Serum | 0.015 | >1 | 0.03 | >1 | 0.12 | 0.5 |
a
In micrograms per milliliter. The serum was 50% human serum.