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. 2022 Apr 21;14:100269. doi: 10.1016/j.mtbio.2022.100269

Fig. 2.

Fig. 2

Biomaterial models and computational tools for simulating lymph node architectures and functions. The lymph node functional zones recapitulated on microfluidic devices including A) paracortex with T cell/dendritic cell interaction (Reproduced with permission [152]. Copyright 2016, The Royal Society of Chemistry), B) paracortex with T-cell zone fibroblastic reticular cells (Reproduced with permission [153]. Copyright 2009, The American Association of Immunologists, Inc.), and C) B-cell follicle (Reproduced with permission [154]. Copyright 2022, Wiley-VCH). D) Confocal images showing T cell (red) interaction and attachment with stromal network (green). Reproduced with permission [164]. Copyright 2015, Wiley-VCH. E) Clearly-segregated T-/B-cell zones and antigen-specific secondary IgG responses are observed in transplanted lymphoid organoid in NP-OVA-preimmunized BALB/c mice. Reproduced with permission [166]. Copyright 2007, American Society for Clinical Investigation. F) Topological structure and tolerance of FRC network and conduit system using small-world network models. Reproduced with permission [170]. Copyright 2020, Elsevier. G) 3D model of the whole lymph node geometry using confocal images and a FRC lattice network model. Reproduced with permission [171]. Copyright 2015, MDPI. H) Body-wide lymphatic network graph model. Reproduced with permission [172]. Copyright 2018, MDPI. (FRC: fibroblastic reticular cell).