Table 3.

Mathematical and computational models for lymph node architectures, features, functions, and diseases.

OBJECT	CONTENT	REFERENCE
LYMPH NODE STRUCTURE AND GEOMETRY	Reticular network	[141,169,[263], [264], [265]]
	Microvascular network and conduit system	[168,170]
	B-cell follicle	[266]
	Cortical sinus	[267]
	Whole lymph node geometry	[171]
	Body-wide lymphatic system	[172]
	Subcapsular sinus	[171]
IMMUNE CELL DYNAMICS AND IMMUNE RESPONSE	T cell motility and dynamics	[103,116,188,[190], [191], [192],196,268,269]
	T cell activation and proliferation	[188,[270], [271], [272]]
	Dendritic cell-T cell interaction (immune response)	[202,271,[273], [274], [275], [276], [277], [278], [279]]
	Stromal cell-immune cell interaction (fibroblastic reticular cells)	[104,141,169,278,280]
	B cell proliferation and activation	[281]
IMMUNE CELL CHEMOTAXIS	T cell motility	[104]
	T cell-dendritic cell contact	[105,202,277]
	Tumor metastasis	[282,283]
	Chemokine gradient formation	[201]
	Stromal cell/fibroblastic reticular cell network	[141]
LYMPH FLOW DYNAMICS	Intra-lymph node flow	[24,201,214,215]
	Lymphatic vessel flow (lymphangion)	[[217], [218], [219], [220], [221], [222], [223],271]
	lymphocyte recirculation	[215]
LYMPH NODE-ASSOCIATED DISEASE	Tumor metastasis through lymph node	[[284], [285], [286]]
	Tumor-immune interplay in lymph node	[139,287,288]
	Lymphoma	[255,256]
	Lymphedema	[260,271,289]
	Lymph node degeneracy	[261]
	Infection	[262,263,290]