Fig. 1.

Study procedure and experimental groups In total, 117 mice were randomly divided over 18 experimental groups: P4HB, PP and sham non-infection at 4, 9 and 60 days (all n ​= ​4 mice with 8 samples per group) and P4HB, PP and sham infection at 4, 9 and 60 days (all n ​= ​9 mice with 18 samples per group). Mice were scored for clinical complications and at sacrifice the mesh tissue complex (MTC) was cut into 3 parts for further analysis: half was used for histology and a quarter was used for quantitative culture of bacteria and storage of the lysate. The remaining quarter was used for storage for future RNA analysis.