Table 3.
Dynamic Sonoclot glass bead (gb)-activated, heparinase (h) treated (paired Sonoclot) parameters on day 1 and day 3
| Sonoclot variable* | Total patients (n=33) | Low flow oxygen (n=2) | High flow oxygen (n=12) | Invasive ventilation (n=19) | P value 1 vs 2 |
P value 1 vs 3 |
| Day 1 | ||||||
| gbACT (s) | 171 (63) | 102 (18) | 135 (28) | 197 (66) | 0.004 | 0.060 |
| gbCR | 38.4 (17.2) | 31.5 (9.2) | 39.3 (17.8) | 38.5 (17.8) | 0.847 | 0.595 |
| gbPF | 2.1 (1.7) | 6.4 (4.5) | 2.1 (1.3) | 1.7 (0.8) | 0.000 | 0.000 |
| gbPeak-Amplitude | 77 (21) | 107 (24) | 98 (17) | 65 (8) | 0.000 | 0.000 |
| gbTime to peak (s) | 13 (3) | 12 (2) | 11 (3) | 15 (3) | 0.001 | 0.117 |
| Day 1 | ||||||
| hACT (s) | 117 (35) | 65 (21) | 101 (34) | 132 (28) | 0.001 | 0.004 |
| CR | 36.5 (12.4) | 34 (11.3) | 38.8 (10.6) | 35.4 (13.7) | 0.729 | 0.888 |
| PF | 2 (1.2) | 1.4 (1.7) | 2.4 (1.6) | 1.8 (1.0) | 0.274 | 0.611 |
| Peak amplitude | 78 (23) | 108 (25) | 102 (19) | 65 (10) | 0.000 | 0.000 |
| Day 3 | ||||||
| gbACT (s) | 163 (57) | 93 (18) | 125 (33) | 187 (53) | 0.001 | 0.023 |
| gbCR | 33.4 (14.3) | 34 (2.8) | 30.2 (13.2) | 35 (15.6) | 0.708 | 0.933 |
| gbPF | 1.6 (1.0) | 2.4 (1.7) | 1.9 (1.4) | 1.3 (0.6) | 0.161 | 0.060 |
| gbPeak amplitude | 78 (19) | 105 (21) | 97 (14) | 66 (10) | 0.000 | 0.000 |
| Time to peak (s) | 15 (5) | 9 (1) | 10 (3) | 18 (3) | 0.000 | 0.001 |
| Day 3 | ||||||
| hACT (s) | 110 (39) | 65 (15) | 82 (38) | 129 (28) | 0.000 | 0.005 |
| hCR | 36.7 (14.9) | 34 (10) | 35.7 (16) | 37 (15.4) | 0.931 | 0.764 |
| Presence of HLE at day 3 (n, %) | 20(63) | 1 (50) | 6 (60) | 13(65) | 0.793 | 0.674 |
| Procoagulant Sonoclot (day 3) (n, %) | 7 (21) | 2 (100) | 4 (40) | 1 (5) | 0.002 | 0.671 |
*Values are expressed as mean±SD and compared using Student t-test, p value<0.05 is considered is significant.
ACT, activated clotting time; CR, clot rate; PF, platelet function.