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. 2022 Apr 2;21(5):100229. doi: 10.1016/j.mcpro.2022.100229

Fig. 4.

Fig. 4

Selected gene and protein expression in EndoC-βH1 cells compared to β cells and insulinomas.A, top 15 PANTHER pathways. B, top 15 PANTHER Protein classes. The percentages indicate the number of proteins annotated with a given PANTHER term versus the total number of proteins quantified in each experiment. C, mRNA expression of endocrine hormones and selected transcription factors. D, protein expression of endocrine hormones and selected transcription factors. β cell proteomics from PXD007569 and RNA-seq from GSE67543. Insulinoma proteomics from (52) and RNA-seq from GSE118014. EndoC-βH1 cells were treated with control nontargeting siRNA and harvested at 72 h Expression cutoff for proteins: quantified in ≥ 3 samples and unambiguously annotated. Sample sizes in EndoC-βH1 experiments: RNA-seq N = 3, TMT proteomics = 3, cell lysate DIA proteomics = 12 replicates. DIA, data-independent acquisition; TMT, tandem mass tag.