TABLE 1.
ZDV and 3TC PK parameters in feline blood plasma after first dose and steady statea
| Analysis group | Tmax (h) | Cmax (μg/ml) | AUC (μg · h/ml) | CLF (liter/h/kg) | t1/2 (h) | VF (liter/kg) |
|---|---|---|---|---|---|---|
| ZDV | ||||||
| Feline (5 mg/kg) first dose | 1.02 (0.05–1.98; 0.55) | 3.67 (2.67–4.66; 4.03) | 10.28 (9.16–11.40; 10.81) | 0.49 (0.43–0.55; 0.46) | 1.69 (1.43–1.94; 1.62) | 1.19 (1.00–1.38; 1.29) |
| Feline (5 mg/kg) steady state | 1.69 (1.28–2.10) | 3.65 (3.54–3.76) | 9.65 (9.13–10.17) | 0.56 (0.52–0.60) | 1.75 (1.60–1.90) | 1.39 (1.37–1.40) |
| Human (3–6 mg/kg) | 0.75 (0.25–1.50) | 1.15 (0.71–1.85) | 1.46 (1.11–1.91) | 2.94 (2.24–4.21) | 2.08 (1.91–2.27) | 1.60 (1.23–1.97) |
| 3TC | ||||||
| Feline (5 mg/kg) first dose | 1.17 (0.31–2.03; 1.02) | 2.86 (2.62–3.08; 2.83) | 8.35 (6.22–10.48; 8.31) | 0.62 (0.46–0.78; 0.60) | 2.39 (1.96–2.83; 2.59) | 2.10 (1.83–2.37; 2.17) |
| Feline (5 mg/kg) steady state | 1.69 (1.28–2.10) | 3.89 (3.27–4.51) | 10.36 (9.03–11.68) | 0.49 (0.46–0.62) | 2.12 (2.09–2.15) | 1.54 (1.27–1.80) |
| Human (1.5–3 mg/kg) | 1.24 (0.50–3.00) | 1.40 (1.17–1.68) | 5.53 (4.58–6.67) | 0.38 (0.29–0.47) | 9.79 (8.51–10.65) | 1.30 (1.07–1.53) |
a
First-dose values include mean (95% confidence interval; median). Steady-state values are calculated from two cats and include mean (range). Human data are as reported in Combivir, zidovudine and lamivudine product information, 2000 (Glaxo Wellcome, Inc.); Cremieux et al., XIIIth Int. AIDS Conf.; and references 19 and 35.