Effects of methylation of flavonoids on affinities.
| Class | Ring | Position | Example | Affinity | Inhibition |
|---|---|---|---|---|---|
| Flavone | A | 6H→OCH3 | Apigenin → hispidulin | ↑ | ↓ |
| Genistein → tectorigenin | ↓ | ↑ | |||
| 8H→OCH3 | Chrysin → wogonin | ↓ | ↑ | ||
| B | 3′H→OCH3 | Tangeretin → nobiletin | ↑ | ↑ | |
| Flavonol | B | 4′OH→OCH3 | Kaempferol → kaempferide | ↓ | ↓ |
| 4′H→OCH3 | Galangin → kaempferide | ↓ | ↓ | ||
| Isoflavone | A | 6H→OCH3 | Daidzein → tectorigenin | ↓ | ↑ |
| B | 4′OH→OCH3 | Daidzein → formononetin | ↓ | ↑ | |
| Genistein → biochanin A | ↓ | ↑ |