FIGURE 8.

Hsa_circ_0072309 promotes the autophagy of glioblastoma in vivo. (A) HE and IHC analyses of p53, p62, and LC3B in orthotopic tumor sections. (B) The weight of tumors was analyzed. *p < 0.05. (C) Mouse survival is shown by Kaplan–Meier curves. P value was calculated by log rank test. (D) Mechanistic model for hsa_circ_0072309 regulating autophagy and TMZ sensitivity. In the context of p53 wild type, hsa_circ_0072309 may inhibits p53 ubiquitination and prevents p53 degradation via sponging miR‐100. With the amount of p53 increased, autophagic cell death is activated and the sensitivity to TMZ is enhanced