FIGURE 2.

Lithium protected the BBB in adult mice with ICH. (A) Representative images of the brain showing EB leakage in control mice with ICH and reduced leakage in mice treated with LiCl at a dose of 3.0 mmol/kg. (B) Quantitation of EB fluorescence. n = 5 mice per group. (C) Quantification of relative IgG signal densities. n = 5 mice per group. (D) Immunofluorescence staining of endogenous plasma IgG (green) leakage from vessels (red) after ICH in mice treated with or without LiCl. (E) Schematic illustration showing where the images in (D) were taken from. Perihematomal regions (indicated by black squares) were selected and imaged. Scale bar, 100 μm. *p < 0.05, **p < 0.01. ICH, intracerebral hemorrhage; BBB, blood–brain barrier