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Bacterial virulence-associated processes targeted by peptidomimetics. (A) Two quorum-sensing systems from Gram-positive bacteria. (B) A representative Gram-negative secretion system. (C) Any phase of biofilm formation. QS, quorum sensing; PM, phospholipid membrane; PG, peptidoglycan cell wall; AIP, autoinducing peptides; OM, outer membrane; and IM, inner membrane.
