Table 2.

Peptidomimetics with anti-biofilm activity at sub-inhibitory concentrations.

Peptidomimetics	MIC (μg.ml−1)	MBIC (μg.ml−1)	Target organism	Mechanism	HC50c (μg.ml−1)	References
mLys/mPhe	8	8	P. aeruginosa	Changes in bacterial surface properties that prevent the attachment Stimulating twitching motility	260.5	Vishwakarma et al., 2021
mLys/mAla	16	8	P. aeruginosa	Changes in bacterial surface properties that prevent the attachment Stimulating twitching motility	>1,250	Vishwakarma et al., 2021
mArg/mPhe	4	4	P. aeruginosa	Changes in bacterial surface properties that preventing the attachment Reducing swarming motility	197.5	Vishwakarma et al., 2021
mArg/mAla	4	4	P. aeruginosa	Changes in bacterial surface properties that prevent the attachment Stimulating twitching motility Reducing swarming motility	551.6	Vishwakarma et al., 2021
Nal-P-113	160	6.25	P. gingivalis W83	Downregulation of genes related to binding proteins, transport, motility and transposases		Wang et al., 2017a
DJK-5	16	1a	P. aeruginosa	Degradation of (p)ppGpp		De La Fuente-Núñez et al., 2015
	1.6	0.8a	E. coli 0157
	8	4a	A. baumannii
	3.2	1.6a	K. pneumoniae
	3.2	0.8a	S. enterica
DJK-6	16	0.5a	P. aeruginosa	Degradation of (p)ppGpp		De La Fuente-Núñez et al., 2015
	16	8a	E. coli 0157
	8	2a	A. baumannii
	4	2a	K. pneumoniae
	4	1a	S. enterica
Ac-Gup-Gup-Nap-Arg-NH2	>5 mM	0.08 (mM)b	P. aeruginosa	Sequestering c-di-GMP		Foletti et al., 2018
Ac-Nap-Gup-Gup-Nap-Arg-NH2	0.156 mM	0.02 (mM)b	P. aeruginosa	Sequestering c-di-GMP		Foletti et al., 2018

^aMinimal biofilm inhibitory concentrations leading to 50% decrease in adherent biofilm growth.

^bMinimal biofilm inhibitory concentrations that inhibited 50% of biofilm growth.

^cHC₅₀: peptidomimetic concentration that produces 50% of hemolysis.