Table 3.
Summary of examples of meta-surface and nanoarray based plasmonic biosensors.
| Surface form | Synthesis method | System/Method | Disease detected | Biomarker | POC ability | Limit of detection | Ref. |
|---|---|---|---|---|---|---|---|
| Meta-substrate | Commercial product (Au), magnetic sputtering method | Plasmonic fluorescence | Cardiac disease | Cardiac troponin I | High | 0.01 ng/mL | [168] |
| Commercial product (Au) | SPR | TB | DIG | High | 63 pg/mL | [169] | |
| Meta-coated slides | Sputtering (Au) | SPR | Dengue | DENV-2 E-proteins | Low | 0.08 pM | [170] |
| Seed-mediated growth on glass slide (Au) | Plasmonic fluorescence | Diabetes | Islet cell–targeting autoantibodies | High | N/A | [171] | |
| Commercial product (Au) | SPR | Cardiac disease | Cardiovascular autoantibodies | Medium | N/A | [172] | |
| Thermal annealing (Ag) | LSPR | Dengue | Dengue NS1 antigen | High | 9 nm/(μg/mL) | [173] | |
| Evaporation (Au) | SPR | Cancer | Carcinoembryonic antigen | High | 5 ng/mL | [174] | |
| Electron beam evaporation, thermal annealing | LSPR | Liver cancer | Liver antigen, liver antibody | High | Antigen 45.24 ng/mL Antibody 25 ng/mL |
[175] | |
| Coating Au on butterfly wings | SERS | Malaria | Malarial hemozoin | Low | N/A | [176] | |
| Nanoarray | Tetrahedron DNA monomers | SPR | HIV | HIV-related DNA | High | 48 fM | [177] |
| Commercial product (Spreeta 2000 chip) | SPR | TB | Ag85 | High | 10 ng/mL | [178] | |
| Commercial product (Au) | SPR | Ebola | mAb1, mAb2, mAb3 | Medium | 0.5 pg/mL | [179] | |
| Seed-mediated growth on glass slide (Au) | SPR | Diabetes | ZnT8A | Low | N/A | [180] |