Figure 10.
a) Structural model of non-hydrolyzed cephalexin bound to NDM-1. Structural model kindly provided by Dr. Nisanth N. Nair.321 b) Structure of cyclobutanone inhibitor bound to SPM-1243 (PDB 5NDB). Zn(II) ions are shown as grey spheres and water molecules / hydroxide ions as red spheres, while bound compounds are shown as colored sticks and protein residues as white sticks (Zn(II) ligands are displayed as thinner sticks). Interactions between the compound and the protein residues and Zn(II) ions are indicated with yellow dashed lines, while coordination interactions of Zn(II) ions by protein residues are shown as green dashed lines.