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. Author manuscript; available in PMC: 2022 Jul 14.
Published in final edited form as: Chem Rev. 2021 Jun 15;121(13):7957–8094. doi: 10.1021/acs.chemrev.1c00138

Figure 14.

Figure 14.

Structures of MBLs from each subclass highlighting key structural features. Zn(II) ions are shown as grey spheres and the metal ligands as white sticks. The L3 loop (and its shorter counterpart in B2 enzymes) is shown in orange, while the α3-β7 loop in B3 enzymes, the L7 loop and the L10 loop are shown in cyan, magenta and red, respectively. The extended α3 helix present in SPM and B2 enzymes is displayed in dark green, and the extended N-terminus in the L1 enzyme is highlighted in blue. PDB codes for the structures: NDM-1 – 4EXY, SPM-1 – 4BP0, CphA – 1X8G, L1 – 1SML, FEZ-1 – 1K07.