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. Author manuscript; available in PMC: 2022 Jul 14.
Published in final edited form as: Chem Rev. 2021 Jun 15;121(13):7957–8094. doi: 10.1021/acs.chemrev.1c00138

Figure 24.

Figure 24.

Structures of VIM-1 (a, PDB 5N5G) and VIM-2 (b, PDB 1KO3) highlighting the positions presenting sequence variation within the VIM-1 and VIM-2 enzyme groups. The positions are colored in the cartoon representation according to increasing absolute frequency of mutation within VIM enzymes belonging to each group. The side chains of those positions with a frequency of substitution in the top 4 categories are shown as sticks.